Plai,
Thoughts and prayers from the Netherlands to your friends wife.
I go with Freddy and advise her to visit the specialists.
Things may sound very bad but there is always hope.
Almost 3 years ago 2 specialists visited me at my hospital bed telling me to enjoy the next coming Christmas
because it was going to be my last , because they discovered a malignant kidney tumor which has spread to my femur bone.
Next December will be my 3rd Christmas after i got that message.
So tell here to never loose faith and get the support of the best medical care possible in Spain ( or abroad ).
Carpe Diem
Cats